Kashani, L., et al. (2012). Saffron for treatment of fluoxetine‐induced sexual dysfunction in women: Randomized double‐blind placebo‐controlled study. So the perfect natural solution for hangovers should be taken before you go out and again when you wake up: Khazdair, M. R., et al. (2015). The effects of Crocus sativus (saffron) and its constituents on nervous system: A review.

The maximum daily dose of saffron is 1,500 mg. This value may be lower in patients with genetic variations that may enhance the effects of saffron [ 67]. I had a horrible migraine-like headache and dizziness after about 4 weeks of use. I was nauseous and overall malice feeling.” Adulteration of Saffron Saffrosun is best taken in the morning after breakfast as it increases the production of serotonin (happy hormone) in the gut and decreases the production of cortisol (stress hormone). Cortisol levels are high in the morning and low at night, so it is important to intervene on its production when it is physiologically high. Also, Saffrosun helps with fatigue and energy levels, taking it in the evening could potentially make your daughter more active. Hence I suggest to take it in the morning for maximum benefit.Also, Saffrosun can be taken on an empty stomach with a drink, however, if your daughter experiences any gastrointestinal tract disturbances, please take it with food.

We only formulate and manufacture based on proven, published human scientific research and clinical trials. Saffron’s potential anti-cancer effects are mediated by the main chemical crocin, which is converted to crocetin in the body. Crocetin can selectively target cancer cells and kill them. It does this by inhibiting the production of cancerous proteins and increasing cell death (apoptosis) [ 45, 47].

Saffron increases levels of proteins required for development, blood flow, and healthy brain activity including BDNF, VEGF, and phosphorylated CREB [ 6].

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Saffron extracts have shown anti-cancer effects in cellular and animal models of lung, liver, breast, pancreatic, colorectal, skin, prostate, ovarian, and cervical cancer [ 45, 46]. The authors concluded that the petal of C. sativus was found to be similarly effective as fluoxetine in the treatment of mild to moderate depression and the study is supportive of other clinical trial studies which demonstrate the antidepressant effect of C. sativus. In muscle cells, saffron increased glucose utilization and the uptake of glucose from the bloodstream. When given alongside insulin, saffron enhanced the activities of insulin and the responsiveness of the cell to insulin [ 62]. Like all our supplements, this remedy is 100% sourced from naturally strengthened foods with no synthetic/artificial chemical ingredients. There is also some evidence to suggest that saffron may help promote weight loss and curb the appetite.

In another study on rats, the daily use of saffron inhibited the production of ulcers caused by excessive histamine or stress [ 53]. The chemical components of saffron are responsible for its health-enhancing effects. However, given the large number of chemicals present, it is not entirely clear how saffron exerts its therapeutic effects [ 1]. A study in the Journal of Behavioral and Brain Science found that a saffron extract increased dopamine levels in the brain without changing the levels of other brain hormones, such as serotonin.

Dinkova-Kostova A. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis. 1999;20(5):911-914.

The probability of obtaining the observed results of a test. The lower the p-value is, the more confident we can be of a true result. For example, a p- value of 0.001 confirms a result as 99.9% accurate. Saffron has commonly been combined with opiates and other pain-relieving substances in traditional medicine [ 57].Study: The Effects of a Saffron Extract on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study12-week, parallel-group, double-blind, randomised controlled trial86 female participants