Best Naturals Alpha Liopic Acid 600 mg 120 Count - ALA Alpha Lipoic Acid Powerful Antioxidant

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In a randomized controlled trial (n = 45), biochemical markers (ie, glutathione levels, malondialdhyde, nitric oxide, tumor necrosis factor-alpha, Fas ligand) associated with the development of diabetic cardiomyopathy were significantly improved in children and adolescents 10 to 14 years of age with asymptomatic type 1 diabetes who received ALA 300 mg twice daily in addition to insulin compared with those who received insulin alone.( 51) Chances are you’ve heard a lot about the many benefits of various antioxidants and high-antioxidant foods — fighting inflammation, helping to beat cancer and so much more — but have you ever wondered what exactly antioxidants are and how they work in the body? A 2013 randomized controlled trial in Iranian patients on maintenance hemodialysis found that 2 months of supplementation with 400 units vitamin E alone and combined with ALA 600 mg significantly decreased one inflammation biomarker, interleukin-6. Biomarkers for lipid peroxidation, malnutrition, and another inflammation biomarker (C-reactive protein) were not significantly affected. Subjective nutritional scores increased significantly with supplement monotherapy or combination therapy.( 55) Dosing

What is it about foods like broccoli and spinach that make them so healthy? There are the fiber, vitamins and minerals, of course, but then there are other important chemical compounds we call “antioxidants,” too — including alpha lipoic acid (ALA). Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive. Recent experiments using rats have shown that ALA can help reverse damage in aging cells of the brain, improve performance in memory tasks, lower oxidative damage and improve mitochondrial function, although we still don’t know how well these benefits can apply to aging humans. 5. Helps Boost Glutathione Because ALA isn’t an official essential nutrient, there hasn’t been an established daily recommendation needed to prevent a deficiency.Evidence shows ALA helps reduce levels of inflammatory proteins called cytokines and increase levels of nitric oxide, which widens blood vessels. This helps to reduce blood pressure. Reducing the Risk of Heart Disease: A review of studies found that alpha-lipoic acid could help lower LDL (bad) cholesterol and triglycerides. Breithaupt-Grogler, K., Niebch, G., Schneider, E., Erb, K., Hermann, R., Blume, H. H., Schug, B. S., and Belz, G. G. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci 1999;8(1):57-65. View abstract.

Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid

Alpha lipoic acid (ALA) is a fat-soluble, sulfur-containing, vitamin-like antioxidant. It is not a true vitamin because it can be synthesized in the body and is not necessary in the diet of animals. ALA functions in the same manner as many B-complex vitamins. Good sources of ALA are yeast and liver. 1, 2 Other sources include spinach, broccoli, potatoes, kidney, heart, and skeletal muscle. 3 History Lee, W. J., Lee, I. K., Kim, H. S., Kim, Y. M., Koh, E. H., Won, J. C., Han, S. M., Kim, M. S., Jo, I., Oh, G. T., Park, I. S., Youn, J. H., Park, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler.Thromb.Vasc.Biol 2005;25(12):2488-2494. View abstract. When taken by mouth: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148. View abstract. Janson, M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv.Aging 2006;1(3):261-265. View abstract.

A 2020 meta-analysis of placebo-controlled trials also found that ALA treatment significantly reduced BMI and body weight and may protect against obesity. Similarly, a 2017 double-blind, placebo-controlled trial found that oral administration of ALA (1,200 mg/day) for eight weeks induced mild weight loss accompanied by a reduction in waist circumference. Risks and Side Effects

Evans, J. L., Heymann, C. J., Goldfine, I. D., and Gavin, L. A. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr.Pract. 2002;8(1):29-35. View abstract. In general, antioxidants may lead to regression of diabetic complications. When ALA was compared with the antioxidant vitamin E, results failed to justify the higher cost of ALA over less expensive and equally effective nutritional antioxidants.( 2) The concentration of ALA in different foods can vary widely depending on where they’re grown, the quality of the soil, how fresh they are and how they’re prepared, so it’s hard to quantify how much is in each type of food. There hasn’t been much research done to draw conclusions about how much ALA is found in particular foods, although we know vegetables and certain organ meats seem to be highest. Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012;30(1):200-211. View abstract. Something that makes ALA unique is that it’s both water-soluble and fat-soluble, unlike other nutrients (like B vitamins or vitamin A, C, D or E). This means it can be properly absorbed despite what types of foods you’re eating, and it can be used in almost all parts of the body.

Research on the effects of ALA supplementation is sparse. What there is, though, does suggest some possible benefits. Here is what's known about the potential health benefits of using alpha-lipoic acid supplements. ALA, the AntioxidantCumulative results in this meta-analysis showed significant reduction of body weight and BMI with ALA treatment compared to placebo, regardless if it was used for weight loss or other purposes. Meta-regression analyses showed that shorter duration of ALA intervention achieved greater BMI reduction than longer interventions. Incidences of side effects and all-cause discontinuation was similar between ALA and placebo. Li J, Xu QL. Effects of shuxuening and -lipoic acid on diabetic peripheral neuropathy. Journal of Modern Drug Application. 2008;2:49-50. Alpha lipoic acid supplementation seems to help improve insulin sensitivity and might also offer protection against metabolic syndrome — a term given to a cluster of conditions like high blood pressure, cholesterol and body weight. Some evidence also shows that it can help lower blood sugar levels. Antidiabetic agents: Alpha-lipoic acid may enhance the hypoglycemic effect of antidiabetic agents. Monitor therapy.( 28, 65, 66, 67, 68, 69, 70, 71, 72, 73)