It’s been used and researched to treat everything from joint pain to weight loss to controlling diabetes in people with insulin insensitivity. Beyond the timeframe of a few months, it’s not clear if you should take berberine indefinitely, and any potential long-term health effects have not been explored in detail. If you’re looking for a quality weight loss supplement sourced from an herbal remedy, berberine is worth a look. Wu M., Wu Y., Deng B., Li J., Zhong G. (2016). Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota. Oncotarget 7 ( 51), 85318. 10.18632/oncotarget.13347

Organic Berberine - manufacturer - undersun Organic Berberine - manufacturer - undersun

Effects of berberine on diseases by regulating intestinal flora. 1. Berberine can activate TLR4/MyD88/NF-κB signal pathway to play an anti-inflammatory role, and increase the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, Alloprevotella, Butyricimonas, Coprococcus, Ruminococcus, Lactobacillus, Akkermansia, Verrucomicrobia, reduce the populations of Bacteroidales, Lachnospiraceae, Rikenellaceae, Desulfovibrio, Streptococcaceae, Clostridiaceae, Prevotella, Proteus, Saccharibacteria, Deferribacteres, Actinobacteria, which affect the development of diabetes. 2. Berberine affects liver diseases by regulating FXR and NF-κB signaling pathways through intestinal flora. 3. Berberine down-regulate F:B ( Firmicutes : Bacteroidetes) and up-regulate SCFA-producing bacteria Allobaculum, Bacteroides, Blautia, Butyricicoccus, Phascolarctobacterium, A. muciniphila and GLP-1R in obesity. 4. Berberine regulates hyperlipidemia by reducing Prevotella, Escherichia, Clostridium Sutterella and increase Bacteroides, Parabacteroides, Blautia, Enterobacter, Akkermansia, Escherichia-Shigella, Incertae sedis, Lachnospiraceae FCS020, Clostridium sensu stricto 1. 5. In Enteropatia, berberine enriched the relative abundance of Firmicutes and decreased Proteobacteria at the phylum level. Meanwhile, berberine increased the propotion of unclassified_f_Porphyromonadaceae, unclassified_f_Lachnospiraceae, Lactobacillus, unclassified_o_Clostridiales, Ruminococcus, Prevotella, Clostridium IV, and decreased Escherichia/Shigella at the genera level. 6. Berberine affect the development of Atherosclerosis by changing the amount of Verrucomicrobia, Akkermansia in Apoe ( −/−) mice fed a high-fat diet in the intestine.

In particular, a number of observational studies have identified an association between elevated circulating levels of branched-chain amino acids (BCAAs) and poor metabolic health. In clinical studies, increased levels of BCAAs in the blood have been positively correlated with insulin resistance ( Lynch and Adams, 2014). Berberine has been shown to reduce the relative abundance of BCAA-producing bacteria, including Clostridiales; the families of Streptococcaceae, Clostridiaceae, the Streptococcus genera, and Prevotella. Consequently, the increased serum levels of BCAAs induced by the consumption of a high-fat diet are reduced significantly following the administration of berberine. Furthermore, data from both healthy subjects and patients with DM indicate that berberine can improve glycemic control and modulate the circulating levels of BCAAs ( Yue etal., 2019). Therefore, it is evident that the hypoglycemic effects of berberine may be related to improvements in the regulation of gut-derived hormones, the weakening of mechanisms in the intestinal mucosal, and the destruction of the immune-barrier. Organic berberine could be an effective antimicrobial agent. A laboratory studyTrusted Source found that berberine helped inhibit the growth of Staphylococcus aureus.S. aureus can cause many health problems, including sepsis, pneumonia, meningitis, and a range of skin conditions.Another studyTrusted Source found that berberine has the ability to damage the DNA and protein of certain bacteria. of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China moc.361@4791nixgnohiuc (H.-X.C.); moc.621@888102nanayuh (Y.-N.H.) Cui H., Cai Y., Wang L., Jia B., Li J., Zhao S., et al.. (2018). Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon. Front. Pharmacol. 9 ( 1), 103. 10.3389/fphar.2018.00571

Berberine: Benefits, supplements, side effects, dosage, and more

Kamada N., Seo S. U., Chen G. Y., Nunez G. (2013). Role of the gut microbiota in immunity and inflammatory disease. Nat. Rev. Immunol. 13 ( 5), 321–335. 10.1038/nri3430

The team behind another studyTrusted Source observed that berberine may activate brown adipose tissue. This tissue helps the body turn food into body heat, and increased activation may help treat obesity and metabolic syndrome.